Detalhe da pesquisa
1.
Negative-Strand RNA Virus L Proteins: One Machine, Many Activities.
Cell
; 162(2): 239-241, 2015 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26186183
2.
Structures, functions and adaptations of the human LINE-1 ORF2 protein.
Nature
; 626(7997): 194-206, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096902
3.
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.
Proc Natl Acad Sci U S A
; 121(15): e2316662121, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38557187
4.
Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Mol Cell
; 66(2): 169-179.e8, 2017 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28392175
5.
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Proc Natl Acad Sci U S A
; 119(27): e2200260119, 2022 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35771941
6.
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
Proc Natl Acad Sci U S A
; 119(30): e2203660119, 2022 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35858448
7.
The RNA polymerase "switch region" is a target for inhibitors.
Cell
; 135(2): 295-307, 2008 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18957204
8.
Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach.
Molecules
; 28(7)2023 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37049868
9.
Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase.
Nucleic Acids Res
; 48(5): 2709-2722, 2020 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31943114
10.
Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation.
Proc Natl Acad Sci U S A
; 116(15): 7308-7313, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30902895
11.
Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase.
J Virol
; 92(13)2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29643235
12.
Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.
Proc Natl Acad Sci U S A
; 112(11): 3475-80, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733891
13.
A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
J Biol Chem
; 291(45): 23569-23577, 2016 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27645997
14.
Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28396546
15.
Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries.
J Antimicrob Chemother
; 71(2): 367-71, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26518047
16.
Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates.
Org Biomol Chem
; 14(8): 2454-65, 2016 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26813581
17.
Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.
Nucleic Acids Res
; 42(12): 8125-37, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24880687
18.
Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.
Antimicrob Agents Chemother
; 59(12): 7184-96, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26324274
19.
Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry.
Anal Chem
; 87(7): 4015-4022, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25763479
20.
Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.
J Virol
; 88(13): 7589-601, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24760888